A New Hydroxy Metabolite of 2-Oxoglutarate Regulates Metabolism in Hypoxia

作者：Harris Adrian L^*

来源：Cell Metabolism, 2015, 22(2): 198-200.

DOI：10.1016/j.cmet.2015.07.016

Two articles in this issue (Intlekofer et al., 2015; Oldham et al., 2015) show a new metabolic pathway regulated by hypoxia, but independently of HIF1 or HIF2. L-2-hydroxyglutarate, produced in hypoxia by malate dehydrogenases and LDHA, is a potent inhibitor of KDM4C, and through redox stress reduces glycolysis.

• 出版日期2015-8-4