Novel C-ring Analogs of Ursolic acid: Synthesis and Cytotoxic Evaluation

作者：Mallavadhani Uppuluri V^*; Pattnaik Banita; Suri Nitasha; Saxena Ajit K

来源：Natural Product Communications, 2014, 9(12): 1687-1690.

DOI：10.1177/1934578x1400901206

• Ursolic acid
• N-bromosuccinamide
• Lactones
• Dienes
• Cytotoxicity

Ursolic acid (1), a natural pentacyclic triterpenic acid, afforded a variety of ring-C transformed products (5-11) when treated with N-bromosuccinimide under the influence of a range of protective groups and solvents. The synthesized compounds have been evaluated for cytotoxic activity against prostate PC 3, leukemia THP 1, cervical Hela and lung A-549 cancer cell lines. Among the tested analogs, compounds 5, 8, 9 and 10 showed potent activity against PC 3, THP 1 and Hela cell lines. Especially, compound 10 showed enhanced activity against the Hela cell line than the parent compound. Compounds 5, 8 and 9 showed comparable activities against PC 3 and THP 1 cell lines.

• 出版日期2014-12