MicroRNA regulation of core apoptosis pathways in cancer

作者：Lima Raquel T; Busacca Sara; Almeida Gabriela M; Gaudino Giovanni; Fennell Dean A; Helena Vasconcelos M

来源：European Journal of Cancer, 2011, 47(2): 163-174.

DOI：10.1016/j.ejca.2010.11.005

• Core apoptosis
• Cancer
• miRNA
• Chemoresistance

Recent research has demonstrated that microRNAs (miRNAs) are key regulators of many cell processes often deregulated in cancer, including apoptosis. Indeed, it is becoming clear that many miRNAs are anti-apoptotic and mediate this effect by targeting pro-apoptotic mRNAs or positive regulators of pro-apoptotic mRNAs. Conversely, many pro-apoptotic miRNAs target anti-apoptotic mRNAs or their positive regulators. We have reviewed the current knowledge in this area including evidence of miRNA involvement in cancer drug resistance.

• 出版日期2011-1