Anticancer Activities of Diphenyl Difluoroketone, a Novel Curcumin Analog, on KB Human Oral Cancer Cells

作者:Jeon Hyun Sang; Jo Myung Hun; Kim Heung Joong; Lee Myoung Hwa; Yu Sun Kyoung; Kim Chun Sung; Lee Sook Young; Kim Su Gwan; Chun Hong Sung; Park Euteum; Kim Do Kyung*
来源:Journal of the Korean Society for Applied Biological Chemistry, 2012, 55(4): 451-456.
DOI:10.1007/s13765-012-1168-8

摘要

Effects of diphenyl difluoroketone (EF-24) and curcumin on cell growth and apoptosis induction in KB human oral cancer cells were examined. EF-24 and curcumin inhibited the growth of KB cells in a dose-dependent manner, and the potency of EF-24 was 30 times greater than that of curcumin. Treatment with EF-24 or curcumin resulted in nuclear condensation and fragmentation. EF-24 and curcumin promoted the proteolytic cleavage of procaspases-3, -7, and -9. Activities of caspases-3 and -7 were detected in living KB cells treated with EF-24 or curcumin. These results suggest that EF-24 and curcumin inhibit cell proliferation and induce apoptosis in KB human oral cancer cells, and have potential properties for development of anti oral cancer drug.

  • 出版日期2012-8