Assessment of cardiac sympathetic activity by MIBG imaging in patients with heart failure: a clinical appraisal

作者：Perrone Filardi Pasquale^*; Paolillo Stefania; Dellegrottaglie Santo; Gargiulo Paola; Savarese Gianluigi; Marciano Caterina; Casaretti Laura; Cecere Milena; Musella Francesca; Pirozzi Elisabetta; Parente Antonio; Cuocolo Alberto

来源：Heart, 2011, 97(22): 1828-1833.

DOI：10.1136/heartjnl-2011-300343

Cardiac sympathetic activity can be assessed by (123)I-labelled meta-iodobenzylguanidine (MIBG) scintigraphy. Abnormalities of sympathetic cardiac activity have been shown in patients with heart failure, resulting in reduced MIBG uptake. Abnormal MIBG uptake predicts cardiac death, arrhythmias and all-cause mortality in patients with heart failure with a prognostic power incremental to that of conventional risk markers, and may identify patients at low risk of arrhythmias despite current guideline indications for implantable cardioverter defibrillator or patients at high risk for arrhythmias not fulfilling implantable cardioverter defibrillator indications. Prospective outcome studies are needed to assess whether MIBG imaging will have an impact on the mortality and morbidity of patients with heart failure.

• 出版日期2011-11