Pyrazole-tethered phosphine ligands for Pd(0): useful catalysts for Stille, Kumada and Hiyama cross-coupling reactions

作者：Pal Anwesha; Ghosh Raju; Adarsh N N; Sarkar Amitabha^*

来源：Tetrahedron, 2010, 66(29): 5451-5458.

DOI：10.1016/j.tet.2010.05.026

• Pyrazolyl-based phosphine ligands
• Palladium complex
• Cross-coupling reaction
• Stille, Kumada, Hiyama

Combination of 3,5-dimethyl-1-(2-(diphenylphosphino)phenyl)-1H-pyrazole, A, and 3-tert-butyl-5-methyl-1-(2-(diphenylphosphino)phenyl)-1H-pyrazole, B, with Pd-2(dba)(3) furnished excellent catalysts for Stille, Kumada and Hiyama cross-coupling reactions. Effects of solvents, bases and ligand/palladium ratio on efficiency of coupling reactions were studied. Molecular structures of palladium(II) complexes of A and B determined by single-crystal X-ray diffraction method revealed a close similarity of ligand arrangement around the metal centre.

• 出版日期2010-7-17