Neuropeptide Y receptor-specifically modulates human neutrophil function

作者：Bedoui Sammy^*; Kromer Andreas; Gebhardt Thomas; Jacobs Roland; Raber Kerstin; Dimitrijevic Mirja; Heine Joern; von Hoersten Stephan

来源：Journal of Neuroimmunology, 2008, 195(1-2): 88-95.

DOI：10.1016/j.jneuroim.2008.01.012

• neuroimmune interactions
• neuropeptide Y (NPY)
• NPY receptors
• human neutrophils
• phagocytosis
• reactive oxygen species

Despite a continuously growing body of evidence highlighting the role of NPY in the immune system, surprisingly little is known about its ability to alter human leukocyte function. We therefore set out to examine NPY receptor expression and functional effects of NPY in freshly isolated human neutrophils. Our results not only demonstrate for the first time the presence of specific NPY receptors on human neutrophils, but also unveil of how these receptors differentially modulate critical functions of neutrophils such as phagocytosis of bacteria as well as the release of reactive oxygen species.

• 出版日期2008-3
• 单位河北医科大学