bla(KPC) RNA Expression Correlates with Two Transcriptional Start Sites but Not Always with Gene Copy Number in Four Genera of Gram-Negative Pathogens

作者：Roth Amanda L; Kurpiel Philip M; Lister Philip D; Hanson Nancy D^*

来源：Antimicrobial Agents and Chemotherapy, 2011, 55(8): 3936-3938.

DOI：10.1128/AAC.01509-10

Klebsiella pneumoniae carbapenemase (KPC)-producing organisms are therapeutically and diagnostically challenging. It is possible that bla(KPC) gene expression plays a role in the variability observed in clinical susceptibility testing. bla(KPC) transformants together with 10 clinical isolates representing four genera were evaluated for bla(KPC) copy number and gene expression and correlated with beta-lactam MIC data. The data suggest that mechanisms other than gene copy number and expression of bla(KPC) contribute to variability in susceptibility when testing KPC-producing isolates.

• 出版日期2011-8