科研之友
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摘要
Two different D-dimer disposable amperometric immunosensing designs based on indirect competitive or sandwich formats and the use of carboxylic acid-modified magnetic beads (COOH-MBs) and screen-printed carbon electrodes (SPCEs) have been developed and compared. In both approaches, the resulting modified MBs were magnetically captured on the surface of a SPCE which was used as the transducer for the electrochemical detection at -0.20 V upon addition of H2O2, and hydroquinone (HQ). Both configurations exhibited linear ranges of clinical usefulness and detection limits quite below the clinical threshold (0.5 mu g?mL-1 D-dimer). The sandwich configuration has been successfully tested with serum samples.
- 出版日期2012-12
