Modulation of the BP Response to Diet by Genes in the Renin-Angiotensin System and the Adrenergic Nervous System

作者：Svetkey Laura P^*; Harris Emily L; Martin Eden; Vollmer William M; Meltesen Gayle T; Ricchiuti Vincent; Williams Gordon; Appel Lawrence J; Bray George A; Moore Thomas J; Winn Michelle P; Conlin Paul R

来源：American Journal of Hypertension, 2011, 24(2): 209-217.

DOI：10.1038/ajh.2010.223

• blood pressure
• DASH
• diet
• genetics
• hypertension
• sodium

BACKGROUND
Essential hypertension results from the interaction of several genetic and environmental factors. Identification of genetic factors that modulate blood pressure (BP) response to interventions can lead to improved strategies for prevention and control. The purpose of this study was to identify genes that modulate BP response to dietary interventions.
METHODS
We used data and samples collected in two randomized feeding studies to determine the extent to which genetic architecture is associated with the effect on BP of sodium intake and the Dietary Approaches to Stop Hypertension (DASH) dietary pattern. Participants in both trials were adults with above-optimal BP or unmedicated stage 1 hypertension. Genomic DNA was typed for several candidate genes.
RESULTS
The effect of sodium intake on BP differed by genotype at the angiotensinogen, beta 2-adrenergic receptor, and kallikrein loci. The effect of DASH dietary pattern on BP differed by genotype at the beta 2-adrenergic receptor locus.
CONCLUSIONS
Thee findings have implications for understanding the mechanism(s) through which diet affects BP, the heterogeneity of these effects, and the extent to which dietary interventions can modulate genetic predisposition.

• 出版日期2011-2