A hand-held beta imaging probe for FDG

作者：Singh Bipin; Stack Brendan C Jr^*; Thacker Samta; Gaysinskiy Valeriy; Bartel Twyla; Lowe Val; Cool Steven; Entine Gerald; Nagarkar Vivek

来源：Annals of Nuclear Medicine, 2013, 27(3): 203-208.

DOI：10.1007/s12149-012-0672-6

• (18)FDG
• PET
• I-131
• Imaging
• Beta probe

Advances in radiopharmaceuticals and clinical understanding have escalated the use of intraoperative gamma probes in surgery. However, most probes on the market are non-imaging gamma probes that suffer from the lack of ancillary information of the surveyed tissue area. We have developed a novel, hand-held digital Imaging Beta Probe (TM) (IBP (TM)) to be used in surgery in conjunction with beta-emitting radiopharmaceuticals such as (18)FDG, I-131 and P-32 for real-time imaging of a surveyed area with higher spatial resolution and sensitivity and greater convenience than existing instruments. %26lt;br%26gt;We describe the design and validation of a hand-held beta probe intended to be used as a visual mapping device to locate and confirm excision of (18)FDG-avid primary tumors and metastases in an animal model. %26lt;br%26gt;We have demonstrated a device which can generate beta images from (18)FDG avid lesions in an animal model. %26lt;br%26gt;It is feasible to image beta irradiation in animal models of cancer given (18)FDG. This technology may be applied to clinical mapping of tumors and/or their metastases in the operating room. Visual image depiction of malignancy may aid the surgeon in localization and excision of lesions of interest.

• 出版日期2013-4