Depth-cumulated epithelial redox ratio and stromal collagen quantity as quantitative intrinsic indicators for differentiating normal, inflammatory, and dysplastic epithelial tissues

作者：Zhuo, Shuangmu; Zheng, Liqin; Chen, Jianxin^*; Xie, Shusen; Zhu, Xiaoqin; Jiang, Xingshan

来源：Applied Physics Letters, 2010, 97(17): 173701.

DOI：10.1063/1.3505762

• FLUORESCENCE SPECTROSCOPY
• MICROSCOPY

Multiphoton microscopy was used to isolate the intrinsic emission contribution of epithelial cellular origins and stromal collagen in normal, inflammatory, and dysplastic epithelial tissues, and quantify the depth-cumulated epithelial redox ratio and stromal collagen quantity. It was found that both inflammatory and dysplastic epithelial tissues display a large decrease in stromal collagen quantity but have very different epithelial redox ratio. These results suggest that probing differences in epithelial redox ratio in addition to stromal collagen quantity can serve as quantitative intrinsic indicators for differentiating normal, inflammatory, and dysplastic epithelial tissues.

• 出版日期2010-10-25
• 单位福建师范大学