Design, synthesis and biological evaluation of novel N1,N8-bis(((4-((5-aryl-1,3,4-oxadiazol-2-yl)methoxy)phenyl)amino)oxy)-1- naphthamide derivatives

作者：Sirgamalla Rambabu; Kommakula Ashok; Banoth Sonyanaik; Dharavath Ravi; Adem Kurumanna; Palithepu Madhu; Boda Sakram^*; Premkumar K

来源：Synthetic Communications, 2018, 48(8): 954-962.

DOI：10.1080/00397911.2018.1432761

• 1,8-Naphthalic anhydride
• biological evaluation
• naphthalene-1
• 8-dicarboxamide derivatives
• phosphoryl chloride

A new series of 1,8-bis(4-((5-phenyl-1,3,4-oxadiazol-2-yl) methoxy)-substituted aryl) naphthalene-1,8-dicarboxamide derivatives (6a-j) were synthesized in the presence of POCl3 and obtained good yields. All the synthesized novel compounds were characterized by IR, H-1 NMR, C-13 NMR, HRMS spectroscopic data and elemental analysis. All the synthesized compounds evaluated for their antibacterial and antifungal activities. The antibacterial activity screened against Gram-positive bacteria Staphylococcus aureus and Gram-negative bacteria Escherichia coli and used standard reference drug ciprofloxacin. The antifungal activity screened against two pathogenic fungal strains Aspergillus niger and Candida albicans used a reference standard drug Voriconazole. All these compounds (6a-j) demonstrate good antibacterial and antifungal activity. Among them, compounds 6h and 6c show highest antibacterial and antifungal activity.
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• 出版日期2018