Anti-cancer activity of 5-O-alkyl 1,4-imino-1,4-dideoxyribitols

作者：Bello Claudia; Dal Bello Giovanna; Cea Michele; Nahimana Aimable; Aubry Dominique; Garuti Anna; Motta Giulia; Moran Eva; Fruscione Floriana; Pronzato Paolo; Grossi Francesco; Patrone Franco; Ballestrero Alberto; Dupuis Marc; Sordat Bernard; Zimmermann Kaspar; Loretan Jacqueline; Wartmann Markus; Duchosal Michel A; Nencioni Alessio; Vogel Pierre^*

来源：Bioorganic & Medicinal Chemistry, 2011, 19(24): 7720-7727.

DOI：10.1016/j.bmc.2011.07.053

• Breast cancer
• Iminoalditols
• JURKAT cells
• Oleyl derivative

New derivatives of 1,4-dideoxy-1,4-imino-D-ribitol have been prepared and evaluated for their cytotoxicity on solid and haematological malignancies. 1,4-Dideoxy-5-O-[(9Z)-octadec-9-en-1-yl]-1,4-imino-Dribitol (13, IC(50) similar to 2 mu M) and its C(18)-analogues (IC(50) < 10 mu M) are cytotoxic toward SKBR3 (breast cancer) cells. 13 also inhibits (IC(50) similar to 8 mu M) growth of JURKAT cells.

• 出版日期2011-12-15