A 1-bp deletion in Fgf5 causes male-dominant long hair in the Syrian hamster

作者：Yoshizawa Yasuhiro; Wada Kenta^*; Shiomi Gaku; Kameyama Yuichi; Wakabayashi Yuichi; Fukuta Katsuhiro; Hashizume Ryoichi

来源：Mammalian Genome, 2015, 26(11-12): 630-637.

DOI：10.1007/s00335-015-9608-5

Hair length in mammals is generally regulated by the hair cycle, and its disruption leads to abnormal hair morphogenesis in several species. FGF5, one of the hair cycle regulators, has a role in inducing catagen, and that mutation causes abnormal hair length in both sexes in humans, mice, dogs, and cats. Male-dominant long-haired coat (MALC) is an inbred strain of Syrian hamster exhibiting spontaneous long hair in males. After castration, MALC exhibited significantly shorter hair than the control individuals, but testosterone administration to castrated MALC showed reversion to the original phenotype. Moreover, flutamide administration led to MALC phenotype repression. Histological analysis revealed that hair follicle regression was shown in the wild-type 4 weeks after depilation, but that of MALC remained in the anagen phase. We detected a c.546delG of Fgf5 in MALC (Fgf5 (malc) ) that might lead to truncation resulting from a frame shift in FGF5 (p.Arg184GlyfsX6). Additionally, homozygous Fgf5 (malc) was only detected in long-haired (Slc:Syrian x MALC)F-2 and (J-2-Nn x MALC)F-2 progenies, and all homozygous wild and heterozygous Fgf5 (malc) individuals showed normal hair length. Thus, Fgf5 (malc) leads to male-dominant long hair via a prolonged anagen phase which is affected by testosterone in hamsters. To our knowledge, this report is the first to present the sexual dimorphism of hair length caused by the Fgf5 mutation.

• 出版日期2015-12