Development of GLP-1 Secretagogue Using Microarray in Enteroendocrine L cells

作者：Kim Kang Hoon; Jang Hyeung Jin^*

来源：BioChip Journal, 2016, 10(4): 272-276.

DOI：10.1007/s13206-016-0403-5

• GLP-1
• Enteroendocrine L cell
• Herbal medicine
• Biochip
• Microarray

Glucagon-like peptide-1 (GLP-1) plays glucose homeostasis and delays gastric empty. Because GLP-1 activates GLP-1 receptor and this activation recruits insulin secretion in pancreatic beta-cells. This biological action applied therapeutic treatment for type 2 diabetes mellitus using GLP-1 analogues, exendin-4 and lilaglutide. Although therapeutic approaches of GLP-1 analogues are very effective as a hypoglycemic agents, its side effects are occurred in clinical study such as pancreatitis, autoimmune hepatitis and acute kidney injury. To solve critical side effects in therapeutic treatment, alternative ways are still developed. In this review, we introduce the character of taste receptors and taste receptor signaling. Because taste receptors and taste receptor signaling are able to induce GLP-1 release from exogenous molecules in enteroendocrine L cells. And how we find and develop that safe exogenous molecules to induce GLP-1 are in natural resources against side effects. We suggest that mRNA variants of taste receptors and taste receptor signaling molecules are briefly screening to find GLP-1 secretagogue in natural components including herbal medicines using biochip in enteroendocrine L cells.

• 出版日期2016-12-20