A New Cytosporone Derivative from the Endophytic Fungus Cytospora sp.

作者：Takano Tomoya; Koseki Takuya; Koyama Hiromasa; Shiono Yoshihito^*

来源：Natural Product Communications, 2014, 9(7): 973-975.

DOI：10.1177/1934578x1400900723

• Endophyte
• Cytosporone E
• 4,5-Dihydroxy-3-heptylphthalide
• Antimicrobial activity
• Cytospora sp.

Japanese oak wilt (JOW) is a tree disease caused by the fungus Raffaelea quercivora, which is vectored by the ambrosia beetle, Platypus quercivorus. In a screening study of the inhibitory active compounds from fungi, a new cytosporone analogue, compound 1, was isolated from the endophytic fungus Cytospora sp. TT-10 isolated from Japanese oak, together with the known compounds, integracin A (2), cytosporones N (3) and A (4). Their structures were determined by extensive 1D- and 2D-NMR spectroscopic and mass spectral analyses. Compound 1 was identified as 4,5-dihydroxy-3-heptylphthalide and named cytosporone E. Compounds 2 and 3 showed antimicrobial activity against Raffaelea quercivora.

• 出版日期2014-7