A novel peptide from TCTA protein inhibits proliferation of fibroblast-like synoviocytes of rheumatoid arthritis patients

作者：Nanke Yuki^*; Yago Toru; Kobashigawa Tsuyoshi; Kawamoto Manabu; Yamanaka Hisashi; Kotake Shigeru

来源：Central European Journal of Immunology, 2014, 39(4): 468-470.

DOI：10.5114/ceji.2014.47730

• osteoclast
• arthritis
• synovium
• translocation-associated gene (TCTA)
• T-cell leukemia

Background: We have demonstrated that a peptide, which we named %26apos;Peptide A%26apos;, derived from the extracellular domain of T-cell leukemia translocation-associated gene (TCTA) protein, inhibited human osteoclastogenesis. %26lt;br%26gt;Objective: In the current study, we examined whether this peptide inhibits the proliferation of rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) or not. %26lt;br%26gt;Material and methods: Fibroblast-like synoviocytes obtained from five RA patients were cultured in the absence or presence of 1, 5, 10 mu g/ml of peptide. We used 29-mer scrambled peptide as a control. %26lt;br%26gt;Results: The peptide inhibited the proliferation of RA FLS dose-dependently. On the other hand, the scrambled peptide showed no inhibition. %26lt;br%26gt;Conclusions: The peptide inhibits both human osteoclastogenesis and the proliferation of RA FLS. Thus, the peptide may be used for the therapy of both osteoporosis and synovitis of RA patients. %26lt;br%26gt;This is the first report of the new peptide we discovered, which inhibits both osteoclastogenesis and synovitis. Thus, this new peptide could be a new drug for patients with both osteoporosis and RA.

• 出版日期2014