Association of sulfonylurea receptor 1 genotype with therapeutic response to gliclazide in type 2 diabetes

作者：Zhang Huijuan^*; Liu Xiaomin; Kuang Hongyu; Yi Ran; Xing Houxun

来源：Diabetes Research and Clinical Practice, 2007, 77(1): 58-61.

DOI：10.1016/j.diabres.2006.10.021

• type 2 diabetes
• polymorphism
• gliclazide

To investigate the effects of sulfonylurea receptor 1 (SUR 1) exon 33 (TCC -> GCC, S1369A) polymorphism on responsiveness to gliclazide. About 115 patients with type 2 diabetes were treated with gliclazide for 8 weeks. SUR1 genotypes were tested by Taqman-PCR. After gliclazide treatment, there was association between T/G polymorphism and decrease of HbA1c. G carriers were more sensitive to gliclazide and the decrease of HbA1c was more significant than TT genotype (TT, 0.76% +/- 1.70%; TG + GG, 1.60% +/- 1.39%, P = 0.044). The polymorphism of SUR IS 1369A was associated with the therapeutic efficacy of gliclazide.

• 出版日期2007-7
• 单位哈尔滨工程大学; 哈尔滨医科大学; 安徽医科大学