Alamandine: a new member of the angiotensin family

作者：Villela Daniel C; Passos Silva Danielle G; Santos Robson A S^*

来源：Current Opinion in Nephrology and Hypertension, 2014, 23(2): 130-134.

DOI：10.1097/01.mnh.0000441052.44406.92

• renin-angiotensin system
• angiotensin-(1-7)
• Mas-related G-coupled receptor type D
• angiotensin A
• alamandine

Purpose of review %26lt;br%26gt;In this article, we review the recent findings regarding a new derivative of angiotensin-(1-7) [Ang-(1-7)], alamandine, and its receptor, the Mas-related G-coupled receptor type D (MrgD) with a special emphasis on its role and how it can be formed. %26lt;br%26gt;Recent findings %26lt;br%26gt;Over the last decade, there have been significant conceptual changes regarding the understanding of the renin-angiotensin system (RAS). A cardioprotective axis has been elucidated by the discovery of the Mas receptor for the biologically active Ang-(1-7), and the angiotensin-converting enzyme 2 (ACE2) that coverts Ang II into Ang-(1-7). In addition, several components of the system, such as Ang-(1-12), Angiotensin A (Ang A) and the newly discovered peptide, alamandine, have been identified. Alamandine is generated by catalysis of Ang A via ACE2 or directly from Ang-(1-7). %26lt;br%26gt;Alamandine is a vasoactive peptide with similar protective actions as Ang-(1-7) that acts through the MrgD and may represent another important counter-regulatory mechanism within the RAS.

• 出版日期2014-3