Diastereoselective and Highly Enantioselective Henry Reactions using C-1-Symmetrical Copper(II) Complexes

作者：Chougnet Antoinette; Zhang Guoqi; Liu Kegang; Haeussinger Daniel; Kaegi Andreas; Allmendinger Thomas; Woggon Wolf D^*

来源：Advanced Synthesis & Catalysis, 2011, 353(10): 1797-1806.

DOI：10.1002/adsc.201100157

• copper(II) complexes
• diastereoselectivity
• enantioselectivity
• Henry reaction
• nitroaldol reaction

Catalytic Henry reactions of aliphatic aldehydes and prochiral nitro compounds were investigated using copper(II) complexes of 14 C-1-symmetrical ligands derived from (1R,2R)(-)-diaminocyclohexane. beta-Nitro alcohols with syn:anti ratios of up to 5.7 and excellent ee values for both diastereosimers were obtained.

• 出版日期2011-7