Acute tetraplegia and cardiac arrest following high cervical leptomeningeal metastasis of giant cell glioblastoma

作者：Ammerman Joshua M; Kerr P Benjamin; Roberti Fabio^*

来源：Journal of Clinical Neuroscience, 2011, 18(8): 1133-1135.

DOI：10.1016/j.jocn.2010.12.034

• Drop metastasis
• Giant cell glioblastoma
• Tetraplegia

Giant cell glioblastoma multiforme (gcGBM) is an unusual subtype of high-grade glioma (grade IV, World Health Organization classification). We report a patient with a rare acute tetraplegia, followed by lethal cardiac arrest, who had undergone a prior resection of a supratentorial gcGBM. Neuroradiological workup revealed a large, high cervical compressive leptomeningeal mass consistent with a drop metastasis. Due to the possibility of a rapid clinical deterioration in patients with high cervical cord compression, the diagnosis of drop metastasis to the spine should be considered in patients with a previous history of supratentorial GBM who present with acute diffuse motor weakness.

• 出版日期2011-8