Dobutamine stress tagging and gradient-echo imaging for detection of coronary heart disease at 3 T

作者：Thomas D^*; Meyer C; Strach K; Naehle C P; Mazraeh J; Gampert T; Schild H H; Sommer T

来源：British Journal of Radiology, 2011, 84(997): 44-50.

DOI：10.1259/bjr/59381313

Objective: The purpose of this study was to evaluate the feasibility and diagnostic accuracy of a combined spoiled gradient-echo (sGRE) and tagged gradient-echo (SPAMM-GRE) protocol for detection of coronary artery disease (CAD) during high-dose dobutamine stress at 3 T.
Method: The study protocol was approved by the local ethics committee. For stress testing, a standard high-dose dobutamine protocol was employed. Image quality at the highest stress level and diagnostic accuracy of the sGRE and SPAMM-GRE sequences were compared The final study population consisted of 37 patients.
Results: The mean image quality score was 2.6 +/- 0.6 for the sGRE sequence and 2.4 +/- 0.6 for the SPAMM-GRE sequence (p>0.05). Sensitivity, specificity and diagnostic accuracy were 0.81, 0.86, 0.84 and 0.88, 0.86, 0.86 for the sGRE and SPAMM-GRE, respectively. In three cases with new wall motion abnormalities (WMAs), detected by sGRE and SPAMM-GRE, WMAs were detected at a lower stress level by tagging.
Conclusion: The combined sGRE and SPAMM-GRE high-dose dobutamine protocol at 3 T is feasible and delivers good diagnostic accuracy. Tagging increases the sensitivity of high-dose dobutamine stress testing for detection of CAD and may allow for detection of new WMAs at lower stress levels compared with sGRE alone.

• 出版日期2011-1