An Update on Direct C-H Bond Functionalization of Nitrogen-Containing Fused Heterocycles

作者：Aziz Jessy; Piguel Sandrine

来源：Synthesis (Germany), 2017, 49(20): 4562-4585.

DOI：10.1055/s-0036-1590859

• heterocycles
• nitrogen
• C-H bond
• direct functionalization
• catalysis
• regioselectivity

This report highlights the recent advances in direct C-H bond functionalization of 5,5- and 6,5-fused heterocycles containing at least two nitrogen atoms. Besides C-C bond formation, C-N, C-S, C-P, and C-Si bonds can also be created via a metal-catalyzed process. Some examples, where a C-H functionalization approach was applied for the synthesis of drug candidates, will be presented as well.
1 Introduction
2 C-H Functionalization Reactions of N-Containing Heterocycles
2.1 Imidazo[1,2-a]pyridines
2.2 Pyrrolo[1,2-a]pyrazines
2.3 Imidazo[1,2-b]pyrazoles
2.4 Imidazo[1,2-a]pyrimidines
2.5 Imidazo[1,2-a]pyrazines and Imidazo[1,5-a]pyrazines
2.6 Imidazo[1,2-b]pyridazines
2.7 Imidazo[4,5-b]pyridines and Imidazo[4,5-c]pyridines
2.8 Pyrazolo[3,4-b]pyridines
2.9 Pyrazolo[1,5-a]pyrimidines
2.10 Pyrrolo[2,3-d]pyrimidines and Pyrrolo[3,2-d]pyrimidines
2.11 Imidazo[1,2-b][1,2,4]triazines
2.12 Imidazo[1,2-b][1,2,4,5]tetrazines
3 Outlook
4 Conclusion

• 出版日期2017-10