Dynamic Kinetic Resolution of beta-Amino Esters by a Heterogeneous System of a Palladium Nanocatalyst and Candida antarctica Lipase A

作者：Engstrom Karin; Shakeri Mozaffar; Backvall Jan E^*

来源：European Journal of Organic Chemistry, 2011, (10): 1827-1830.

DOI：10.1002/ejoc.201001714

• Dynamic kinetic resolution
• beta-Amino esters
• Candida antarctica lipase A
• Palladium
• Nanocatalysts
• Heterogeneous catalysis

A dynamic kinetic resolution (DKR) of beta-amino esters have been developed by the use of a heterogeneous racemization catalyst and an immobilized enzyme that accepts aromatic, heteroaromatic and aliphatic substrates. The reaction conditions were optimized to yield an efficient catalytic system without by-product formation. The products are obtained in 96-99% ee and high yields.

• 出版日期2011-4