Decreased hippocampal expression of calbindin D-28K and cognitive impairment in MELAS

作者：Emmanuele Valentina; Garcia Cazorla Angels; Huang Hua Bin; Coku Jorida; Dorado Beatriz; Cortes Etty P; Engelstad Kristin; De Vivo Darryl C; Di Mauro Salvatore; Bonilla Eduardo; Tanji Kurenai^*

来源：Journal of the Neurological Sciences, 2012, 317(1-2): 29-34.

DOI：10.1016/j.jns.2012.03.005

• Mitochondria
• MELAS
• Cognitive dysfunction
• Calbindin
• Hippocampus
• Calcium-binding protein
• Mitochondrial DNA

Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) is a maternally inherited mitochondrial syndrome characterized by seizures, migrainous headaches, lactic acidosis, vomiting, and recurrent stroke-like episodes. Patients often suffer from cognitive dysfunction of unclear pathogenesis. In this study, we explored a possible link between cognitive dysfunction and hippocampal expression of calbindin D-28KD (CB), a high affinity calcium-binding protein, in four MELAS patients, using post mortem hippocampal tissues. We found significantly reduced CB levels in all patients by immunohistochemistry, Western blot, and quantitative real-time PCR. Reduction in CB expression has been associated with aging and with neurodegenerative disorders, including Alzheimer%26apos;s disease. We postulate that the reduced CB expression may play a role in the cognitive abnormalities associated with MELAS.

• 出版日期2012-6-15