A revised amino group pK(a) for prymnesins does not provide decisive evidence for a pH-dependent mechanism of Prymnesium parvum's toxicity

作者：Cichewicz Robert H^*; Hambright K David

来源：Toxicon, 2010, 55(5): 1035-1037.

DOI：10.1016/j.toxicon.2010.02.002

A reconsideration of the pKa values proposed by Valenti et al. (Theodore W. Valenti et al., A mechanistic explanation for pH-dependent ambient aquatic toxicity of Prymnesium parvum carter. Toxicon (2010) 55, 990-998) suggests that the ionization status of the C-14 amino group in prymnesins will not substantially influence the toxicity of these compounds over a pH range of 6.5-8.5. A revised pKa value and ionization state distribution for the prymnesins in aqueous systems is proposed.

• 出版日期2010-5