Molecular Iodine-Mediated Domino Reaction for the Synthesis of Benzamides, 2,2-Diazidobenzofuran-3(2H)-ones and Benzoxazolones

作者：Rajendar K; Kant Ruchir; Narender T^*

来源：Advanced Synthesis & Catalysis, 2013, 355(18): 3591-3596.

DOI：10.1002/adsc.201300668

• benzamides
• benzoxazolones
• Curtius rearrangement
• 2
• 2-diazidobenzofuran-3(2H)-ones
• Haller-Bauer reaction
• iodine
• sodium azide

A simple and efficient domino protocol has been developed for the preparation of biologically important benzamides, 2,2-diazidobenzofuran-3(2H)-ones and benzoxazolones from various structurally and electronically divergent acetophenones and ortho-hydroxyacetophenones in the presence of molecular iodine, sodium azide and sodium bicarbonate at 100 degrees C in good to excellent yields.

• 出版日期2013-12-16