A twin study of the trough plasma steady-state concentration of metformin

作者：Stage Tore B^*; Damkier Per; Pedersen Rasmus S; Christensen Mette M H; Christiansen Lene; Christensen Kaare; Brosen Kim

来源：Pharmacogenetics and Genomics, 2015, 25(5): 259-262.

DOI：10.1097/FPC.0000000000000133

• metformin
• pharmacogenetics
• pharmacokinetics
• twin study

Objective The aim of this study was to determine the intrapair similarity in trough steady-state plasma concentrations of metformin in monozygotic and dizygotic twin pairs.
Methods We included 16 twin pairs (eight monozygotic and eight dizygotic twin pairs) for this study after contacting 524 twin pairs. They were dosed with metformin to steady state (1 g twice daily) for 6 days and on day 7, the trough concentration of metformin was determined 12 h after the last dose.
Results There was no strong intrapair similarity in trough steady-state plasma concentrations of metformin in either dizygotic or monozygotic twin pairs.
Conclusion The trough steady-state plasma concentration of metformin does not appear to be tightly genetically regulated. The interpretation of this finding is limited by the small sample size.

• 出版日期2015-5