Administrative data on diagnosis and mineralocorticoid receptor antagonist prescription identified patients with primary aldosteronism in Taiwan

作者:Wu, Vin Cent; Hu, Ya Hui; Wu, Che Hsiung; Kao, Chih Chin; Wang, Cheng Yi; Yang, Wei Shen; Lee, Hsiu Hao; Chang, Yuan Shian; Lin, Yen Hung; Wang, Shuo Meng*; Chen, Likwang; Wu, Kwan Dun
来源:Journal of Clinical Epidemiology, 2014, 67(10): 1139-1149.
DOI:10.1016/j.jclinepi.2014.05.012

摘要

Objectives: To develop algorithms of locating patients with primary aldosteronism (PA) using insurance reimbursement data and to validate the algorithms using medical charts. Study Design and Setting: We extracted National Health Insurance (NHI) reimbursement data and medical charts in seven enrolled hospitals and analyzed diagnosis-related information for 1999-2010. The NHI codes PA as 255.1x, using the International Classification of Diseases, Ninth Revision, Clinical Modification. Confirmation of PA was based on suppression tests. Results: We reviewed medical charts for 1,094 cases with at least one PA diagnosis. PA was confirmed for 563 cases. Compared with patients with essential hypertension, PA patients had higher systolic blood pressure, higher aldosterone, lower renin activity, and lower potassium level (all P-values < 0.05). An algorithm based on PA diagnosis reported in at least one hospital stay or three outpatient visits had modest performance (sensitivity = 0.94 and specificity = 0.20). The best additional condition for the algorithm was use of mineralocorticoid receptor antagonist (MRA; sensitivity = 0.89 and specificity = 0.88). Conclusion: Using information on PA diagnosis and MRA prescription reported in insurance claims data can precisely locate PA patients in high-risk groups. This algorithm can construct a reliable PA sample for conducting research in various fields, including epidemiology and clinical practice.

  • 出版日期2014-10