Adverse oncologic effects of intraoperative transfusion during pancreatectomy for left-sided pancreatic cancer: the need for strict transfusion policy

作者：Hwang Ho Kyoung; Jung Myung Jae; Lee Sung Hwan; Kang Chang Moo^*; Lee Woo Jung

来源：Journal of Hepato-Biliary-Pancreatic Sciences, 2016, 23(8): 497-507.

DOI：10.1002/jhbp.368

• Pancreatectomy
• Pancreatic cancer
• Survival
• Transfusion

BackgroundThe aim of the present study was to investigate the prognostic impact of transfusion following distal pancreatectomy (DP) for left-sided pancreatic ductal adenocarcinoma (PDAC).
MethodsRetrospective analysis was performed to identify prognostic factors in patients who underwent DP from July 1992 to October 2012.
ResultsForty-eight patients were male, and 35 were female with a mean age of 62 9 years. Twenty-three (27.7%) of the patients received intraoperative blood transfusion. In univariate analysis, combined organ resection (P = 0.046), intraoperative transfusion (P<0.001), pathologic tumor size (3cm, P = 0.051), clinical tumor size (3cm, P = 0.008), lymph node metastasis (P = 0.021), lymph node ratio (LNR0.017, P<0.001), and tumor differentiation (P = 0.013) were analyzed to predict tumor recurrence. Multivariate analysis showed that lymph node metastasis (Exp() = 2.136, P = 0.016), LNR (Exp() = 2.003, P = 0.049), and intraoperative transfusion (Exp() = 2.793, P = 0.001) were independent prognostic factor predicting tumor recurrence. The amount of estimated blood loss was closely associated with intraoperative transfusion (P < 0.001).
ConclusionIntraoperative transfusion should be avoided by gentle operative handling to minimize intraoperative bleeding, and the appropriate transfusion policy should be followed to increase the survival outcome.

• 出版日期2016-8