Detection of Cryptococcus neoformans Capsular Antigen in HIV-Infected Patients in the State of Para in the North of Brazil

作者：da Costa Maurimelia M; Madeira Lucimar di Paula; Feitosa Rosimar N M; Ishak Marluisa de Oliveira G; Ishak Ricardo; da Silva Silvia H M; Vallinoto Antonio C R^*

来源：Current HIV Research, 2013, 11(8): 647-651.

• Cryptococcus neoformans
• HIV-1/AIDS
• latex agglutination test

Cryptococcus neoformans is an important cause of morbidity in HIV-infected patients worldwide. In the northern region of Brazil, the prevalence of this infection is poorly known due to a lack of systematic investigations. This study aimed to determine the occurrence of cryptococcosis by detecting antigenaemia in HIV-infected patients in the State of Para, Brazil. A latex Cryptococcus antigen detection kit was used to test 418 serum samples from HIV-infected patients seen at two Infectious Disease Specialized Units in the State of Para. The C. neoformans antigenaemia prevalence was 2.6%, and titres reached 1:8. The cases occurred mainly in asymptomatic females, and 45% presented CD4(+) T lymphocyte counts of fewer than 200 cells/mm(3). These results show the importance of early C. neoformans antigenaemia detection to prevent fungal disease.

• 出版日期2013-12