The efficacy of mizoribine for the treatment of rheumatoid arthritis and its correlation with renal function

作者：Terai Chihiro^*; Tsutsumi Tomomi; Sakurai Tadashi; Moriguchi Masato; Azuma Takanori; Kaneko Motohide; Kawagoe Mitsuhiro; Hoshi Kenta; Yoshida Hide; Matsui Toshimichi; Nakajima Kyoichi; Okuyama Ayumi; Nishi Eiko; Amano Koichi; Ota Muneo; Mimura Toshihide; Chino Kentaro; Aoki Kazutoshi; Handa Yuichi; Hirose Tatsuo; Kida Issei; Kobayashi Shigeto; Suzuki Kimihiro; Matsuzaki Tsuyoshi; Kuga Yoshiaki

来源：Modern Rheumatology, 2014, 24(6): 892-896.

DOI：10.3109/14397595.2014.885376

• Cystatin-C
• DAS
• Mizoribine
• Renal function
• Rheumatoid arthritis

Objectives. To evaluate the correlation between the efficacy of mizoribine (MZR) and the factors that might effect MZR concentration: renal function and dosage and administration of MZR in patients with rheumatoid arthritis (RA). %26lt;br%26gt;Methods. The efficacy of MZR treatment was prospectively evaluated in 97 RA regardless of dosage, at the 14 participated institutions. The Disease Activity Score 28-CRP3 was used to assess RA activity. The renal function was evaluated based on the serum creatinine and serum cystatin-C (Cys-C). The patients were followed up for 24 weeks. %26lt;br%26gt;Results. The patients with a mean age 66.2 years included 18 male. The renal function assessment showed increased creatinine in 16.4% of patients and increased Cys-C in 54.5%, suggesting the higher sensitivity of Cys-C to detect impaired renal function than creatinine. In patients with good or moderate response according to the European League against Rheumatism classification criteria, the Cys-C was significantly higher compared with those with no response. MZR treatment was significantly more effective in patients with an arithmetic product of the single MZR dose used and Cys-C of 179 or more. %26lt;br%26gt;Conclusions. The efficacy of MZR may increase in proportion to its single dose, or increased Cys-C level in patients with impaired renal function.

• 出版日期2014-11