ANTIOXIDANT AND FREE RADICAL SCAVENGING ACTIVITY OF H. OFFICINALIS L. VAR. ANGUSTIFOLIUS, V. ODORATA, B. HYRCANA AND C. SPECIOSUM

作者：Ebrahimzadeh Mohammad Ali^*; Nabavi Seyed Mohammad; Nabavi Seyed Fazel; Bahramian Fatemeh; Bekhradnia Ahmad Reza

来源：Pakistan Journal of Pharmaceutical Sciences, 2010, 23(1): 29-34.

• Antioxidant activity
• DPPH
• H. officinalis
• C. speciosum
• V. odorata
• B. hyrcana

Extracts of 4 medicinal and aromatic plants were investigated for their antioxidant potency employing six various established in vitro system: H. officinalis L. var. angustifolius aerial parts, C. speciosum flowers, V. odorata and B. hyrcana leaves. With regard to IC(50) values (mu g/ ml), the order in DPPH radical-scavenging were CS (585.6) > HO (311) > VO (245.1) > and BH (113.1). Effectiveness in reducing powers were high and in a descending order of HO > CS > BH > VO (at the concentrations of 25-800 mu g/ ml). IC(50) for Fe(2+) chelating ability were 188, 750 and 980 mu g/ ml for VO, CS and HO, respectively. BH extract has shown only 38% inhibition at 800 mu g/ ml. The extracts showed weak nitric oxide-scavenging activity. All extracts exhibited very low and moderate concentration-dependent antioxidant activity in FTC methods. IC(50) for scavenging of H(2)O(2) were 169 for BH, 175 for CS, 640 for VO and 663 mu g/ ml for HO. The content of total phenolic compounds and flavonoids were measured in plant extracts. The data obtained in the in vitro models clearly establish the antioxidant potency of all extracts.

• 出版日期2010-1