Design, synthesis and biological evaluation of novel indano- and thiaindano-pyrazoles with potential interest for Alzheimer's disease

作者:Genest David; Rochais Christophe*; Lecoutey Cedric; Santos Jana Sopkova de Oliveira; Ballandonne Celine; Butt Gueulle Sabrina; Legay Remi; Since Marc; Dallemagne Patrick
来源:Medchemcomm, 2013, 4(6): 925-931.
DOI:10.1039/c3md00041a

摘要

The synthesis of eighteen novel (thia)indanopyrazole derivatives was achieved starting from amino(thia)indanones. Some of them displayed a dual binding site acetylcholinesterase inhibition which makes them potentially interesting for Alzheimer's disease treatment.

  • 出版日期2013-6