Birefringence measurement of the retinal nerve fiber layer by swept source polarization sensitive optical coherence tomography

作者：Elmaanaoui Badr^*; Wang Bingqing; Dwelle Jordan C; McElroy Austin B; Liu Shuang S; Rylander Henry G III; Milner Thomas E

来源：Optics Express, 2011, 19(11): 10252-10268.

DOI：10.1364/OE.19.010252

A Swept Source Polarization-Sensitive Optical Coherence Tomography (SS-PS-OCT) instrument has been designed, constructed, and verified to provide high sensitivity depth-resolved birefringence and phase retardation measurements of the retinal nerve fiber layer. The swept-source laser had a center wavelength of 1059 nm, a full-width-half-max spectral bandwidth of 58 nm and an A-line scan rate of 34 KHz. Power incident on the cornea was 440 mu W and measured axial resolution was 17 mu m in air. A multiple polarization state nonlinear fitting algorithm was used to measure retinal birefringence with low uncertainty. Maps of RNFL phase retardation in a subject measured with SS-PS-OCT compare well with those generated using a commercial scanning laser polarimetry instrument. Peak-to-valley variation of RNFL birefringence given here is less than values previously reported at 840nm.

• 出版日期2011-5-23