A new dehydroabietic acid-based arylamine fluorescent probe: Synthesis, structure analysis and in vitro biodiagnose function

作者：Gao, Hong; Chen, Shanshan; Rao, Xiaoping; Shang, Shibin; Song, Zhanqian^*

来源：Bioorganic & Medicinal Chemistry Letters, 2013, 23(7): 2254-2259.

DOI：10.1016/j.bmcl.2013.01.035

• Dehydroabietic acid-based arylamine
• Synthesis
• Structure
• Fluorescent probe

A new fluorescent probe (methyl 13-(alpha-naphthalene)aminodeisopropyldehydroabietate) has been synthesized, and its structure was optimized by theoretical DFT calculation and determinated by single-crystal X-ray diffraction analysis. The optimized data are in agreement with the experimental values. The fluorescence properties, photostability, cell toxicity and in vitro fluorescence imaging of the compound have been investigated. The results indicated that it can be effectively taken up by HeLa, 7721, 7901 and A549 cells and strong blue fluorescence signals were detected in these cells.

• 出版日期2013-4-1
• 单位中国林业科学研究院; 中国林业科学研究院林产化学工业研究所; 南京师范大学