Does menopausal hormone therapy reduce myocardial infarction risk if initiated early after menopause? A population-based case-control study

作者：Carrasquilla German D^*; Berglund Anita; Gigante Bruna; Landgren Britt Marie; de Faire Ulf; Hallqvist Johan; Leander Karin

来源：Menopause-The Journal of the North American Menopause Society, 2015, 22(6): 598-606.

DOI：10.1097/gme.0000000000000354

• Menopausal hormone therapy
• Cardiovascular diseases
• Myocardial infarction
• Menopause
• Epidemiology
• Biological markers

Objective: This study aims to assess whether the timing of menopausal hormone therapy initiation in relation to onset of menopause and hormone therapy duration is associated with myocardial infarction risk.
Methods: This study was based on the Stockholm Heart Epidemiology Program, a population-based case-control study including 347 postmenopausal women who had experienced a nonfatal myocardial infarction and 499 female control individuals matched for age and residential area. Odds ratios (with 95% CIs) for myocardial infarction were calculated using logistic regression.
Results: Early initiation of hormone therapy (within 10 y of onset of menopause or before age 60 y), compared with never use, was associated with an odds ratio of 0.87 (95% CI, 0.58-1.30) after adjustments for lifestyle factors, body mass index, and socioeconomic status. For late initiation of hormone therapy, the corresponding odds ratio was 0.97 (95% CI, 0.53-1.76). For hormone therapy duration of 5 years or more, compared with never use, the adjusted odds ratio was 0.64 (95% CI, 0.35-1.18). For hormone therapy duration of less than 5 years, the odds ratio was 0.97 (95% CI, 0.63-1.48).
Conclusions: Neither the timing of hormone therapy initiation nor the duration of therapy is significantly associated with myocardial infarction risk.

• 出版日期2015-6