Decarboxylative Synthesis of Functionalized Oxindoles via An Iron-Initiated Radical Chain Process and Application in Constructing Diverse Fused-Indoline Heterocycles

作者：Cui, Zhihao; Du, Da-Ming^*

来源：Advanced Synthesis & Catalysis, 2018, 360(1): 93-99.

DOI：10.1002/adsc.201700976

• FeCl2 center dot 4H(2)O
• Peresters
• Oxindoles
• Fused-indoline-heterocycle skeletons
• Electron catalysis

Rapid construction of diverse fused-indoline-heterocycle (FIH) frameworks including high-value pyrroloindolines, furoindolines and thienoindolines in a two-step sequence has been described. The key to success hinges on the adoption of peresters as alpha-heteroatom alkyl radical precusors, which can smoothly react with N-arylacrylamides via a radical chain process initiated by inexpensive FeCl2 center dot 4H(2)O to afford the functionalized oxindoles, the key intermediates to FIH skeletons. The approach features operationally-simplicity, broad substrates scope and mild conditions.

• 出版日期2018-1-4
• 单位北京理工大学