Fabrication of Electrochemical Sensor for Hyaluronic Acid Determination

作者：Chen, Chen; Li, Junfang; Bai, Xiaoli; Pei, Ke; Wang, Mingyue; Zhao, Hongqiao; Yang, Linlin; Wang, Caie^*

来源：International Journal of Electrochemical Science, 2017, 12(8): 7777-7785.

DOI：10.20964/2017.08.38

• Electrochemical sensor
• Graphene
• Zinc oxide
• Hyaluronan
• Gecko extract

This work employed a facile one-pot hydrothermal method to prepare a reduced graphene oxide-ZnO nanorods composite (RGO-ZnO). Glassy carbon electrode (GCE) was modified by the obtained nanocomposite, which was then used to realize the selective and sensitive detection of hyaluronan (HY). The fabricated biosensor was linearly related to HY concentration (1-800 mu M), with a limit of detection (LOD) of 0.42 mu M (S/N = 3). This biosensor for HY was stable, reproducible and characteristic of anti-interference. Furthermore, the proposed biosensor has potential for further application in HY detection in gecko extract specimens.

• 出版日期2017-8
• 单位河南大学