Acupuncture suppresses reinstatement of morphine-seeking behavior induced by a complex cue in rats

作者：Lee Bong Hyo^*; Lim Sung Chul; Jeon Hyeon Jeong; Kim Jae Su; Lee Yun Kyu; Lee Hyun Jong; In Sunghyun; Kim Hee Young; Yoon Seong Shoon; Yang Chae Ha

来源：Neuroscience Letters, 2013, 548: 126-131.

DOI：10.1016/j.neulet.2013.05.026

• Environment
• Cue
• Acupuncture
• Morphine
• Reinstatement
• GABA

Morphine causes physical and psychological dependence for individuals after repeated-use. Above all, our previous study showed that acupuncture attenuated reinstatement of morphine-seeking behavior induced by pharmacological cue. In this study, we investigated whether acupuncture could suppress the reinstatement of morphine-seeking behavior induced by the combination of environmental and pharmacological cues and the possible neuronal involvement. Male Sprague-Dawley rats were trained to self-administer morphine (1.0 mg/kg) for 3 weeks. Following the withdrawal phase (7 days), the effects of acupuncture on reinstatement of morphine-seeking behavior were investigated. For the investigation of neuronal involvement, the GABA(A) receptor antagonist bicuculline and the GABA(B) receptor antagonist SCH 50911 were pre-treated. Morphine-seeking behavior induced by combination of re-exposure to the operant chamber and morphine injection was suppressed perfectly by acupuncture at SI5, but not at the control acupoint LI5 and this effect was blocked by pre-treatment with the GABA receptor antagonists. This study suggests that acupuncture at SI5 can be considered as a predominant therapy for the reinstatement of morphine-seeking behavior in humans.

• 出版日期2013-8-26