MicroRNA control of nodal signalling

作者：Martello Graziano; Zacchigna Luca; Inui Masafumi; Montagner Marco; Adorno Maddalena; Mamidi Anant; Morsut Leonardo; Soligo Sandra; Tran Uyen; Dupont Sirio; Cordenonsi Michelangelo; Wessely Oliver; Piccolo Stefano^*

来源：Nature, 2007, 449(7159): 183-U1.

DOI：10.1038/nature06100

MicroRNAs are crucial modulators of gene expression, yet their involvement as effectors of growth factor signalling is largely unknown. Ligands of the transforming growth factor-beta superfamily are essential for development and adult tissue homeostasis. In early Xenopus embryos, signalling by the transforming growth factor-beta ligand Nodal is crucial for the dorsal induction of the Spemann's organizer. Here we report that Xenopus laevis microRNAs miR-15 and miR-16 restrict the size of the organizer by targeting the Nodal type II receptor Acvr2a. Endogenous miR-15 and miR-16 are ventrally enriched as they are negatively regulated by the dorsal Wnt/beta-catenin pathway. These findings exemplify the relevance of microRNAs as regulators of early embryonic patterning acting at the crossroads of fundamental signalling cascades.

• 出版日期2007-9-13