New cytotoxic cyclic peroxide acids from Plakortis sp marine sponge

作者：Hoye Thomas R; Alarif Walied M; Basaif Salim S; Abo Elkarm Mohamed; Hamann Mark T; Wahba Amir E; Ayyad Seif Eldin N^*

来源：ARKIVOC, 2015, 2015(5): 164-175.

DOI：10.3998/ark.5550190.p008.948

• Plakortis sponge
• polyketides
• cyclic peroxides
• cytotoxicity

Bioassay-guided fractionation of the extract of Jamaican marine sponge Plakortis sp. followed by preparative TLC and HPLC yielded several known methyl ester cyclic peroxides (1a, 2a, 3a, 4, 5), known plakortides (6,7), known bicyclic lactone (8) and new cyclic peroxide acids (1b, 2b, 3b). The chemical structures were elucidated by extensive interpretation of their spectroscopic data. These natural products showed remarkable in vitro cytotoxicity against several cancer cell lines.

• 出版日期2015