Hypothyroidism as a risk factor for open angle glaucoma: A systematic review and meta-analysis

作者：Wang Shiming; Liu Yue; Zheng Guangying^*

来源：PLos One, 2017, 12(10): e0186634.

DOI：10.1371/journal.pone.0186634

Purpose
The relationship between hypothyroidism and primary open angle glaucoma (POAG) has attracted intense interest recently, but the reported results have been controversial. This meta-analysis was carried out to determine the association between hypothyroidism and POAG.
Methods
The literature was identified from three databases (Web of Science, Embase, and PubMed). The meta-analyses were performed using random-effects models, with results reported as adjusted odds ratios (ORs) with 95% confidence intervals (CI 95%).
Results
A total of 11 studies meeting the inclusion criteria were included in the final meta-analysis. The pooled OR based on 11 risk estimates showed a statistically significant increased risk of POAG prevalence among individuals with hypothyroidism (OR = 1.64, 95% CI = 1.27-2.13). Substantial heterogeneity among these studies was detected (P < 0.001; I-2 = 83.2%). Sub-group analysis revealed that the cohort studies and case-control studies showed a significant association between hypothyroidism and POAG, which was not observed in cross-sectional studies. There was no significant publication bias in this study.
Conclusions
The findings of this meta-analysis indicate that individuals with hypothyroidism have an increased risk of developing POAG.

• 出版日期2017-10-25
• 单位郑州大学