科研之友
微信
新浪微博
Facebook
分享链接
摘要
The gonadotrophic hormones,FSH and LH play separating but complementary roles in the regulation of the folliculogenesis and steroidgenesis,leading to follicular recruitment and selection,resulting in growth and maturation in a spontaneous menstrual cycle and during ovulation induction.In assisted reproduction techniques,however,the relative importance of threshold of FSH and LH during the follicular phase is still subject to extensive debate,and questions surrounding the optimal amount of FSH and LH in stimulation protocols using down-regulation by GnRH-a combined with gonadotrophin protocol.From experimental and clinical evidence it seems unequivocal that the flay up stage of GnRH-a action is helpful for enhancing follicular recruitment and prolonging the window of FSH threshold value,but the down-regulation stage action is correlated with suppressed LH level resulting in individual defect in ovulation stimulated.Another document is long-acting GnRH-a preparation including the full or a half-dosage has more profound pituitary desensitization than one-third dosage of long-acting and potent or short-acting preparations,which the serum LH level <0.5 IU/L at different study points during the follicular phase.
- 出版日期2008
- 单位中山大学附属第一医院
