Antimicrobial susceptibility of Enterobacteriaceae, including molecular characterization of extended-spectrum beta-lactamase-producing species, in urinary tract isolates from hospitalized patients in North America and Europe: results from the SMART study 2009-2010

作者：Hoban Daryl J^*; Lascols Christine; Nicolle Lindsay E; Badal Robert; Bouchillon Sam; Hackel Meredith; Hawser Stephen

来源：Diagnostic Microbiology and Infectious Disease, 2012, 74(1): 62-67.

DOI：10.1016/j.diagmicrobio.2012.05.024

• Urinary tract infection
• Extended
• Spectrum beta
• Lactamase
• Enterobacteriaceae

In 2009-2010, 3646 urinary tract isolates of Enterobacteriaceae spp. were isolated from hospitalized patients in North America and Europe. Extended-spectrum beta-lactamase (ESBL) production was detected in 8.5% wand 8.8% of Escherichia coli and Klebsiella pneumoniae, respectively, in North America and in 17.6% and 38.9% for Europe. respectively. The carbapenems (ertapenem and imipenem) were the most active agents in vitro. with ampicillin-sulbactam the least active. Molecular characterization of about 50% of ESBL-positive isolates identified the presence of bla(CTX-M) genes in over 90% of Escherichia coli from both continents. bla(KPC) was more common in North American isolates of K. pneumoniae than in European isolates (21.4% versus 6.9%). bla(TEM) and AmpC genes were infrequent. Enterobacteriaceae spp. isolated from hospitalized patients with urinary tract infections in both North America and Europe are often resistant to commonly used antimicrobials with bla(CTX-M) genes common in both Escherichia colt and K. pneumoniae.

• 出版日期2012-9