Absorption and Metabolism of Piceatannol in Rats

作者：Setoguchi Yuko^*; Oritani Yukihiro; Ito Ryouichi; Inagaki Hiroyuki; Maruki Uchida Hiroko; Ichiyanagi Takashi; Ito Tatsuhiko

来源：Journal of Agricultural and Food Chemistry, 2014, 62(12): 2541-2548.

DOI：10.1021/jf404694y

• piceatannol
• resveratrol
• absorption
• metabolism
• passion fruit
• stilbene

Piceatannol (trans-3,3',4,5'-tetrahydroxystilbene), a natural analogue of resveratrol, has multiple biological functions. Nevertheless, piceatannol's biological fate is yet to be determined. In this study, we evaluated the absorption and metabolism of piceatannol in rats. Furthermore, the area under the plasma concentration curves (AUC) and metabolic pathway of piceatannol were compared with those of resveratrol. We determined the plasma concentrations of piceatannol, resveratrol, and their respective metabolites following their intragastric administration. Resveratrol metabolites were only conjugates, whereas piceatannol metabolites were piceatannol conjugates, O-methyl piceatannol, and its conjugates. The AUC for piceatannol, resveratrol, and their metabolites increased in a dose-dependent manner (90-360 mu mol/kg). The AUC for total piceatannol was less than that for total resveratrol, whereas the AUC for piceatannol (8.6 mu mol.h/L) after piceatannol and resveratrol coadministration was 2.1 times greater than that for resveratrol (4.1 mu mol.h/L). The greater AUC for piceatannol was a result of its higher metabolic stability.

• 出版日期2014-3-26