Neuroendocrine carcinoma of the urinary bladder. A case report

作者：Rogelio Aragon Tovar Anel; Eli Pineda Rodriguez Marco; Edgardo Puente Gallegos Francisco; Zavala Pompa Angel

来源：Cirugia y Cirujanos, 2014, 82(3): 338-343.

• Carcinoma
• neuroendocrine
• small cell
• urinary bladder

Background: Small cell carcinoma of the urinary bladder is an infrequent lesion.
Clinical case: We present the case of a 68-year-old male who arrived at the emergency room with a history of 24-h gross hematuria. Imaging studies show a urinary bladder tumor with a 218 cc volume that during a 20-day period increased to 426 cc. Histopathological images with hematoxylin-eosin show an infiltrating solid mass with uneven borders. It is composed of neoplastic cells with evident nuclei predominance and scant cytoplasm (small cells). Chromogranin immunohistochemical staining shows a diffusely positive cytoplasmic granular pattern on neoplastic cells. High molecular weight cytokeratin staining shows a negative pattern on neoplastic cells along with a positive pattern on surrounding normal urothelium. Tumoral mass is positive for synaptophysin and CD-56 and negative for CK-7 and CK-20. Patient therapy was based on radiation plus chemotherapy.
Conclusion: Small cell carcinoma of the urinary bladder represents 0.35-0.70% of urinary bladder tumors. Histological and immunohistochemical identification are key elements in the diagnosis. Treatment approach is based on cisplatin-based chemotherapy plus radical cystectomy, except when metastatic disease is present.

• 出版日期2014-6