Alternative therapeutic approaches: hepatoprotective effect of neriumoleander extract in thioacetamide induced hepatotoxicity

作者：Akhtar Tasleem; Sheikh Nadeem^*; Abbasi Muddasir Hassan

来源：International Journal of Clinical and Experimental Medicine, 2016, 9(8): 16118-16124.

• Hepatotoxicant
• hepatoprotective
• cytotoxicity
• necrosis
• infiltration
• thioacetamide

In the folk medicine system different parts of Nerium oleander are utilized for the treatment of a variety of human disorders. In this study, the therapeutic potential of aqueous extract of N. oleander leaves extract was assessed in thioacetamide (TAA) directed chronic hepatotoxicity in Wistar rats. TAA administration caused severe hepatic damage as evidence from significant decrease in level of serum total protein, albumin, ALT, total lipids, HDL (30%, 32%, 37%, 37% & 48% respectively) and concurrent rise in ALP and bilirubin total (129% & 153% respectively). The results illustrated that the treatment of N. oleander effectively increased the TAA induced low levels of serum total protein, albumin, ALT, total lipids, HDL (12%, 24%, 64%, 46% & 53% respectively) and reduced the TAA induced serum level of ALP and bilirubin total (66% & 35% respectively). Histopathology of hepatic tissues displayed that N. oleander extract has lessened the occurrence of liver lesions, along with infiltration, cloudy swelling of hepatic cells and low degree of hepatic necrosis induced by TAA in rats. While histochemical findings revealed blue stained hemosiderin granules in the peripheral area of hepatic lobules and mainly in Kupffer cells in TAA treated group while lesser degree of iron deposition was observed after the use of N. oleander leaves extract. Findings suggest that N. oleander leaves extract has significant hepatoprotective activity, as evident by biochemical parameters and histopathological studies.

• 出版日期2016