Pinocembrin protects endothelial cells from oxidized LDL-induced injury

作者：Su, Qiang; Sun, Yuhan; Ye, Ziliang; Yang, Huafeng; Kong, Binghui; Li, Lang^*

来源：Cytokine, 2018, 111: 475-480.

DOI：10.1016/j.cyto.2018.05.033

• Atherosclerosis
• Oxidized low-density lipoprotein (ox-LDL)
• Inflammation
• Reactive oxygen species (ROS)
• p38
• NF-kappa B

Oxidized low-density lipoprotein (ox-LDL) is a major risk factor for atherosclerosis and often causes injury to vascular endothelial cells. We found that pinocembrin, a natural antioxidant found in honey and certain herbs, protects human aortic endothelial cells (HAECs) from ox-LDL-induced injury. Pinocembrin suppresses the expression of pro-inflammatory vascular adhesion molecules (VCAM-1, ICAM-1 and E-selectin) and cytokines (TNF-alpha, IL-1 beta, and IL-8), as well as ROS production induced by ox-LDL. Pinocembrin potently inhibits the attachment of monocytes to HAEC cells. Mechanistically, pinocembrin suppresses activation of the MAPK kinase p38 and NF-kappa B pathways in the context of ox-LDL. Our data indicate that pinocembrin is a promising versatile natural compound that can protect endothelial cells from injury.

• 出版日期2018-11
• 单位广西医科大学